In 1953, Jimmy Takata (Nishikawa) suffers from "battle fatigue" (Post Traumatic Stress Disorder), to the great concern of his wife, Mary (Tomita). Raised in Hawai'i, Takata and some of his friends enlisted in the 100th Battalion, serving in the European Theater of Operations. In a series of flashbacks, he remembers the war and events in his life surrounding it. Following a head injury, he begins to have visions, and believes that he is seeing memories of other men, including his friend Fred...

《毁灭战士4》由id Tech 6引擎制作，游戏的世界更加庞大，敌人将更加难应付，游戏场面更为血腥，同时射击感也更加优秀。 　　多人模式可以自建游戏元素，包括装甲、建筑及怪物等，将带给玩家高度定制玩的游戏体验。还加入了名为Snapmap的地图自定义模式，允许自定义多人对战地图。